QBREXZA cloth is a topical prescription anticholinergic medicine used on the skin to treat excessive underarm sweating (primary axillary hyperhidrosis) in adults and children 9 years of age and older.

It is not known if QBREXZA is safe and effective in children under 9 years of age.

The main active ingredient in QBREXZA, glycopyrronium, is a competitive inhibitor of acetylcholine receptors that are located on certain peripheral tissues, including sweat glands. This means QBREXZA blocks the “sweat signals” sent to certain sweat glands, inhibiting the action of acetylcholine on those glands and thereby reducing the extent of sweating.

Do not use QBREXZA if you have certain medical conditions that can be made worse by taking an anticholinergic medicine, such as glaucoma, severe ulcerative colitis, or certain other serious bowel problems associated with severe ulcerative colitis, myasthenia gravis, or Sjogren’s syndrome.

Talk to your healthcare provider if you are not sure if you have a medical condition that can be made worse by taking an anticholinergic medicine. Please ask your healthcare provider for more information.

Before using QBREXZA, tell your healthcare provider about all of your medical conditions, including if you:

  • have prostate or bladder problems, or problems passing urine
  • have kidney problems
  • are pregnant or plan to become pregnant. It is not known if QBREXZA will harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if QBREXZA passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby during treatment with QBREXZA

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

QBREXZA may affect the way other medicines work, causing side effects. Especially tell your healthcare provider if you take anticholinergic medicines.

Know the medicines you take. Keep a list of your medicines with you and show it to your healthcare provider and pharmacist when you get a new medicine.

QBREXZA can cause serious side effects, including:

  • New or worsened urinary retention. People who use QBREXZA may develop new or worse urinary retention. Urinary retention can be caused by a blockage in your bladder. Urinary retention can also happen in men who have a larger-than-normal prostate. Symptoms of urinary retention may include:
    • difficulty urinating
    • urinating frequently
    • urination in a weak stream or drips
    • full bladder or difficulty emptying your bladder (distended bladder)

If you have these symptoms, stop using QBREXZA and call your healthcare provider right away.

  • Problems with control of your body temperature. QBREXZA can cause you to have decreased sweating in areas other than the underarm area, which could cause you to become overheated and to develop heat illness. When in hot or very warm temperatures, watch for generalized lack of sweating and avoid use if you are not sweating in these situations. Symptoms of heat illness include:
    • hot, red skin
    • decreased alertness or passing out (unconsciousness)
    • fast, weak pulse
    • fast, shallow breathing
    • increased body temperature (fever)

Stop using QBREXZA and call your healthcare provider right away if you develop any of these symptoms.

  • Blurred vision. If you develop blurred vision during treatment with QBREXZA, call your healthcare provider, stop using QBREXZA, and do not drive, operate machinery, or do hazardous work until your vision is clear.

The most common side effects of QBREXZA include:

  • dry mouth
  • dilation of the pupils of your eyes (mydriasis)
  • sore throat
  • skin redness, burning/stinging, or itching in underarm area
  • headache
  • problems with urination
  • blurred vision
  • nasal dryness
  • throat, eye, and skin dryness
  • constipation

These are not all of the possible side effects of QBREXZA. Call your healthcare provider for medical advice about side effects.

The active ingredient in QBREXZA is glycopyrronium tosylate. The inactive ingredients are citric acid, dehydrated alcohol, purified water, and sodium citrate.

Only your healthcare provider can tell you if QBREXZA is right for you. If you think you sweat more than normal under your arms, or if your underarm sweating is bothersome and/or interferes with daily activities, ask your healthcare professional about options for treating it, including QBREXZA, and if QBREXZA is right for you.


How should I use QBREXZA?

  • Use QBREXZA exactly as your healthcare provider tells you to use it
  • QBREXZA comes as a single-use, pre-moistened cloth in individual pouches
  • QBREXZA should be applied to the clean, dry, intact skin of your underarm areas only. Do not apply QBREXZA to broken skin. Do not cover the treated area with a plastic (occlusive) dressing
  • Apply QBREXZA to both underarm areas with 1 cloth, 1 time every 24 hours

Applying QBREXZA:

  • Carefully tear open the pouch to avoid tearing the QBREXZA cloth
  • Unfold the QBREXZA cloth and apply QBREXZA by wiping across 1 entire underarm 1 time. Using the same QBREXZA cloth, wipe across the other underarm 1 time
  • Throw away (discard) the used QBREXZA cloth in the trash
  • Wash your hands right away with soap and water after you apply QBREXZA and have thrown away the cloth. It is important that you wash your hands because the QBREXZA that is still on your hands can cause you to have blurred vision if you touch your eyes
  • Do not reuse the QBREXZA cloth

Most people should use it under both underarms since primary axillary hyperhidrosis usually occurs equally under both arms. However, you should always consult with your healthcare professional about how to use QBREXZA.

QBREXZA is an anticholinergic. Using other anticholinergic medicines while using QBREXZA may lead to unwanted side effects. Tell your doctor about any other medications that you may be taking.

QBREXZA may cause you to have blurred vision that is temporary. If you develop blurred vision, call your healthcare provider, stop using QBREXZA, and do not drive, operate machinery, or do hazardous work until your vision is clear.

QBREXZA is flammable. Avoid heat and flame while applying QBREXZA to your skin.

You should use QBREXZA once a day, or as directed by your doctor.

There is no recommended time of day to use QBREXZA. However, in order to help you remember to use it every day, it’s best to make it part of your daily routine. For example, add it to your “washing up” routine before going to bed each night.

It is important that you throw the towelette away immediately after use and wash your hands with soap and water. If any medication is left on your hands and comes in contact with your eyes, blurred vision could result.

Make sure the garbage bin is not accessible by pets or small children.

QBREXZA is not meant to take the place of deodorants or antiperspirants. Talk to your healthcare professional for more specifics on using QBREXZA with your current deodorant or antiperspirant.

Please check the carton your QBREXZA pouches come in for an expiration date.

  • Store QBREXZA at room temperature between 68°F and 77°F (20°C and 25°C)
  • QBREXZA is flammable. Keep QBREXZA away from heat and flame

Keep QBREXZA and all medicines out of the reach of children.


QBREXZA can be prescribed by primary care physicians or dermatologists. Consult with the healthcare specialist that you feel most comfortable with.

Your primary source of information on excessive underarm sweating and QBREXZA should be your healthcare professional.

Woman pulling the QBREXZA (glycopyrronium) cloth towelette out of the packet. Woman pulling the QBREXZA (glycopyrronium) cloth towelette out of the packet.

How to use QBREXZA

Follow these simple steps to less sweat

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